Intrauterine transfusion in Rh-isoimmunization.

Intrauterine transfusion in Rh-isoimmunization.

Fifteen per cent. of all cases of Rh-isoimmunization end in stillbirth. Until 1963 the only available means of preventing this outcome in cases with a high risk of stillbirth was to deliver the foetus prematurely before intrauterine death had occurred. The value of this was limited, because many intrauterine deaths due to haemolytic disease of the newborn occur early in pregnancy, and because i...

[Intrauterine transfusion].

Congenital cytomegalic inclusion disease following intrauterine transfusion.

Congenital cytomegalic inclusion disease occurring in two infants who received intrauterine transfusions for severe haemolytic disease due to rhesus isoimmunization may have been transmitted in the donor blood.

Immunosuppressive therapy in Rh-incompatible transfusion.

Postpartum injections of 250 ,tg of anti-D gammaglobulin prevent Rh-immunization of Rh-negative women, with an im-munosuppression success rate of approximately 95% (Eklund and Nevanlinna, 1971). The average fetomaternal transfusion, however, is less than 1-5 ml in 98% of cases (Clarke et al., 1966), and so far there are few observations on trying to suppress primary Rh-immunization due to massi...

Bronchopleural fistula following intrauterine transfusion.

An infant developed a bronchopleural fistula following intrauterine transfusion given for severe haemolytic disease of the newborn. The fistula was shown to be due to the transfusion being given into the right pleural cavity and lung. Initial treatment along conservative lines is suggested, reserving thoracotomy and lobectomy for use if these simple measures fail. Hypocalcaemia was a complicati...